Schapiro is a surname, and may refer to:
- Alexander Schapiro, Russian anarchist
- Miriam Schapiro, A Canadian-Born, American Artist
- Boris Schapiro, British bridge player
- J. Salwyn Schapiro, American historian
- Leonard Schapiro, British historian
- Mary Schapiro, American SEC chair (2009-)
- Morris Schapiro, American chess master
- Sascha Schapiro, Ukrainian anarchist