Major League Career
After spring training in Atlanta, Georgia, Castleton was one of five pitchers used in an opening game against the Philadelphia Athletics. After pitching a hitless inning, he was selected as starting pitcher for an exhibition game with Newark. Unfortunately, he performed poorly and was sent back to Atlanta for additional experience. Once there, Castleton pitched formidably in the Southern Association, winning 10 of 13 decisions for Atlanta, despite earlier inactivity due to a sore arm. At the close of the Southern Association's season, Castleton was called to rejoin the New York Highlanders, where he made two starts in the last week of the American League season. In his first start, during a contest with the St. Louis Browns, Castleton allowed five hits, striking out two, and walking one. Despite New York's 3–1 loss to the Browns, the pitcher gained positive reviews. During his second start, in a match with the Chicago White Sox, Castleton allowed six hits, striking out three and walking one.
Despite Castleton's solid pitching, manager Griffith chose to option Castleton to Atlanta for additional seasoning—a decision that had unexpectedly tragic implications for Castleton's career. After a strong start, Castleton suffered a bout with typhoid fever that left him in uncertain health from that point on. His poor health contributed to an inconsistent record, which resulted in his eventual release to Cincinnati in 1909. In the only game of a scheduled doubleheader with Boston (the other games had been cancelled due to inclement weather), Castleton finished with four strikeouts and only one walk. Unfortunately, this was followed by a disastrous appearance in a July 25 bout with St. Louis. Continual health problems that evidently resulted from his 1908 illness impeded his performance, and he was forced to endure long periods of inactivity.
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