Rhoa

RHOA

Identifiers Symbols RHOA; ARH12; ARHA; RHO12; RHOH12 External IDs OMIM: 165390 MGI: 1096342 HomoloGene: 68986 ChEMBL: 6052 GeneCards: RHOA Gene

Gene Ontology
Molecular function	• GTPase activity • protein binding • GTP binding • myosin binding • protein domain specific binding
Cellular component	• nucleus • mitochondrion • cytosol • cytoskeleton • plasma membrane • cell cortex • lamellipodium • cell junction • axon • midbody • cleavage furrow • ruffle membrane • apical junction complex
Biological process	• response to hypoxia • regulation of transcription from RNA polymerase II promoter • cell-matrix adhesion • transforming growth factor beta receptor signaling pathway • small GTPase mediated signal transduction • Rho protein signal transduction • axon guidance • skeletal muscle tissue development • blood coagulation • response to mechanical stimulus • response to glucose stimulus • virus-host interaction • actin cytoskeleton organization • platelet activation • positive regulation of cell growth • regulation of cell migration • positive regulation of cell migration • androgen receptor signaling pathway • positive regulation of actin filament polymerization • stress-activated protein kinase signaling cascade • negative regulation of intracellular steroid hormone receptor signaling pathway • regulation of osteoblast proliferation • cleavage furrow formation • positive regulation of NF-kappaB import into nucleus • response to drug • positive regulation of I-kappaB kinase/NF-kappaB cascade • negative regulation of I-kappaB kinase/NF-kappaB cascade • stress fiber assembly • response to amino acid stimulus • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process • apical junction assembly • negative regulation of neuron apoptotic process • positive regulation of neuron apoptotic process • ossification involved in bone maturation • response to ethanol • negative regulation of neuron differentiation • positive regulation of neuron differentiation • positive regulation of translation • positive regulation of cell adhesion • positive regulation of vasoconstriction • neurotrophin TRK receptor signaling pathway • phosphatidylinositol-mediated signaling • regulation of axonogenesis • negative regulation of axonogenesis • positive regulation of axonogenesis • regulation of dendrite development • regulation of small GTPase mediated signal transduction • response to glucocorticoid stimulus • positive regulation of stress fiber assembly • regulation of calcium ion transport • trabecula morphogenesis • positive regulation of podosome assembly • spindle assembly involved in mitosis
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 387 11848 Ensembl ENSG00000067560 ENSMUSG00000007815 UniProt P61586 Q9QUI0 RefSeq (mRNA) NM_001664 NM_016802 RefSeq (protein) NP_001655 NP_058082 Location (UCSC) Chr 3:
49.4 – 49.45 Mb Chr 9:
108.31 – 108.34 Mb PubMed search

Ras homolog gene family, member A (RhoA) is a small GTPase protein known to regulate the actin cytoskeleton in the formation of stress fibers. In humans, it is encoded by the gene RHOA.