History
RPMA was first introduced in 2001 in a paper by Lance Liotta and Emanuel Petricoin who invented the technology. The authors used the technique to successfully analyze the state of pro-survival checkpoint protein at the microscopic transition stage using laser capture microdissection of histologically normal prostate epithelium, prostate intraepithelial neoplasia, and patient-matched invasive prostate cancer. Since then RPMA has been used in many basic biology, translational and clinical research. In addition, the technique has now been brought into clinical trials for the first time whereby patients with metastatic colorectal and breast cancers are chosen for therapy based on the results of the RPMA. This technique has been commercialized for personalized medicine-based applications by Theranostics Health, Inc.
Dr. Liotta has patented 50 of his inventions and invention ideas throughout the years. These patents range from kids toys to highly advanced biological instruments. In addition to his plethora of patents he has over 200 scientific publications ranging from new methods of treatment to nano particles capable of killing cancer cells.
Read more about this topic: Reverse Phase Protein Lysate Microarray
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