RBC may refer to:
- Rare Breeds Canada, a Canadian non-profit organization dedicated to preserving rare breeds of Canadian livestock
- 12e Régiment blindé du Canada, a Canadian Forces armored regiment in Valcartier, Quebec
- Rayleigh-Bénard convection
- Real business cycle
- Recognition by Components Theory
- Red blood cell, the most numerous cell in the human body, that carries oxygen in the blood
- Reformed Bible College or Kuyper College, a college in Grand Rapids, Michigan
- Regional Broadband Consortium, an English administrative entity for the development of broadband connections to schools
- Resin-based composite, a plastic material used in dentistry
- Richard Bland College
- Roanoke Bible College of Elizabeth City, North Carolina
- Robinvale Airport's IATA code
- Role-based collaboration, a computer programming philosophy used in security, as well as service oriented software
- Rotating biological contactor, a biological process for wastewater treatment
- Royal Bank of Canada
- Royal Bank Cup, a hockey tournament sponsored by the Royal Bank of Canada
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