Quackenbush is surname that refers to:
- Bill Quackenbush (1922–1999), Canadian professional hockey player
- Chuck Quackenbush (b. 1954), American politician from California; state insurance commissioner and state assemblyman
- Dave Quackenbush (contemporary), American punk rock singer
- Henry Quackenbush (1847–1933), American industrialist
- John A. Quackenbush (1828–1908), American politician from New York; U.S. representative 1888–1893
- Mike Quackenbush (contemporary), American pro wrestler
- Robert Quackenbush (b. 1929), American children's author
- Robert Quackenbush (Wisconsin politician), (1923-2006) American politician from Wisconsin