QB can refer to:
- Quarterback, a position in American and Canadian football
- Queen's Bench, a legal term defining court cases
- Quest Beat, a game software label
- QuickBASIC, a programming language
- Quiet Birdmen, a secret club for male aviators in the U.S.
- Sky Georgia's IATA code
- Queensbridge, Queens
- Queens, a borough of New York City
- Queens Boulevard, a street in the Queens borough of New York City
- ATCvet code QB Blood and blood forming organs, a section of the Anatomical Therapeutic Chemical Classification System for veterinary medicinal products
- Quebec is sometimes abbreviated as QB, although its official postal code is QC
- QuickBooks, accounting software
- Kyubey, a character in Japanese animation Puella Magi Madoka Magica