QB can refer to:

  • Quarterback, a position in American and Canadian football
  • Queen's Bench, a legal term defining court cases
  • Quest Beat, a game software label
  • QuickBASIC, a programming language
  • Quiet Birdmen, a secret club for male aviators in the U.S.
  • Sky Georgia's IATA code
  • Queensbridge, Queens
  • Queens, a borough of New York City
  • Queens Boulevard, a street in the Queens borough of New York City
  • ATCvet code QB Blood and blood forming organs, a section of the Anatomical Therapeutic Chemical Classification System for veterinary medicinal products
  • Quebec is sometimes abbreviated as QB, although its official postal code is QC
  • QuickBooks, accounting software
  • Kyubey, a character in Japanese animation Puella Magi Madoka Magica