Deficiency
Genetic defects of this enzyme cause the disease known as pyruvate kinase deficiency. In this condition, a lack of pyruvate kinase slows down the process of glycolysis. This effect is especially devastating in cells that lack mitochondria, because these cells must use anaerobic glycolysis as their sole source of energy because the TCA cycle is not available.
One example is red blood cells, which in a state of pyruvate kinase deficiency rapidly become deficient in ATP and can undergo hemolysis. Therefore, pyruvate kinase deficiency can cause hemolytic anemia.
Read more about this topic: Pyruvate Kinase
Famous quotes containing the word deficiency:
“Free verse leaves out the meter and makes up
For the deficiency by church intoning.
Free verse, so called, is really cherished prose....”
—Robert Frost (1874–1963)
“Shakespeare’s fault is not the greatest into which a poet may fall. It merely indicates a deficiency of taste.”
—Denis Diderot (1713–1784)
“If a man is a good lawyer, a good physician, a good engineer ... he may be a fool in every other capacity. But no deficiency or mistake of judgment is forgiven to a woman ... and should she fail anywhere, if she has any scientific attainment, or artistic faculty, instead of standing her interest as an excuse, it is censured as an aggravation and offence.”
—E.P.P., U.S. women’s magazine contributor. The Una, p. 28 ( February 1855)