Publication Bias - Remedies

Remedies

Ioannidis' remedies include:

  1. Better powered studies
    • Low-bias meta-analysis
    • Large studies where they can be expected to give very definitive results or test major, general concepts
  2. Enhanced research standards including
    • Pre-registration of protocols (as for randomized trials)
    • Registration or networking of data collections within fields (as in fields where researchers are expected to generate hypotheses after collecting data)
    • Adopting from randomized controlled trials the principles of developing and adhering to a protocol.
  3. Considering, before running an experiment, what they believe the chances are that they are testing a true or non-true relationship.
    • Properly assessing the false positive report probability based on the statistical power of the test
    • Reconfirming (whenever ethically acceptable) established findings of "classic" studies, using large studies designed with minimal bias

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