PRP may stand for:
- Park Royal Partnership in London
- Patriotic Renewal Party or Partido Renovación Patriótica, a political party in Honduras
- Peel Regional Police
- People's Reconciliation Party
- People's Republic of Poland
- Personnel Reliability Program
- Petroleum Remediation Product
- Pityriasis rubra pilaris, a rare skin disorder
- Platelet-rich plasma
- Pleasure Ridge Park, Louisville
- Portuguese Republican Party
- Potentially Responsible Party
- Praja Rajyam Party
- Prion protein(PRNP or PrP), a major constituent of the infectious prion
- Probable prime
- Professional Registered Parliamentarian
- Progressive Reform Party (disambiguation), various political parties
- Progressive rubella panencephalitis
- Proline rich proteins
- Pseudorandom permutation
- Psychological refractory period
- Parallel Redundancy Protocol, the IEC 62439-3 data network protocol that provides seamless fault-tolerance