Structure
The catalytic subunits of many protein kinases are highly conserved, and several structures have been solved.
Eukaryotic protein kinases are enzymes that belong to a very extensive family of proteins that share a conserved catalytic core. There are a number of conserved regions in the catalytic domain of protein kinases. In the N-terminal extremity of the catalytic domain there is a glycine-rich stretch of residues in the vicinity of a lysine amino acid, which has been shown to be involved in ATP binding. In the central part of the catalytic domain, there is a conserved aspartic acid, which is important for the catalytic activity of the enzyme.
Read more about this topic: Protein Kinase
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