Pocono may refer to:
- The Poconos, a mountainous region in northeastern Pennsylvania
- Pocono Creek, a tributary of Brodhead Creek in the Poconos
- Pocono Biological Laboratories, a company related to Sanofi pasteur
- Pocono Raceway, a superspeedway in the Poconos
- The Pocono 500, a NASCAR race held at Pocono Raceway
- USS Pocono (AGC-16), a United States Navy amphibious force command ship in commission from 1945 to 1971