Published Clinical Research Studies Using PiB
| Year | Title | Summary | Authors | Journal |
|---|---|---|---|---|
| 2004 | Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B | Retention of PiB shown to be approximately 2-fold greater in cortical areas of AD subjects relative to controls. Pattern of retention mirrors the pattern of amyloid deposition known from post-mortem studies. | Klunk, W.E., H. Engler, A. Nordberg, Y. Wang, G. Blomqvist, D.P. Holt, M. Bergstrom, I. Savitcheva, G.F. Huang, S. Estrada, B. Ausen, M.L. Debnath, J. Barletta, J.C. Price, J. Sandell, B.J. Lopresti, A. Wall, P. Koivisto, G. Antoni, C.A. Mathis, and B. Langstrom | Ann Neurol 55:306-19 |
| 2005 | Kinetic modeling of amyloid binding in humans using PET imaging and Pittsburgh Compound-B. | Metholodogy paper describing appropriate methods for the quantification of PiB brain scans. First report using PiB in subjects categorized with mild cognitive impairment (MCI). | Price, J.C., W.E. Klunk, B.J. Lopresti, X. Lu, J.A. Hoge, S.K. Ziolko, D.P. Holt, C.C. Meltzer, S.T. DeKosky, and C.A. Mathis | J Cereb Blood Flow Metab 25: 1528-1547 |
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