PFI may stand for:
- Pagan Federation International
- Pellet Fuels Institute, a trade association that serves the wood pellet fuel industry
- Percy FitzPatrick Institute of African Ornithology
- Pharmaceutical Formulation Intermediates (PFIs)
- Popular Front Of India, a confederation of organisations in India
- Private finance initiative, a method for funding public sector projects with private capital
- The Prize Fighter Inferno, a side project of Coheed and Cambria frontman, Claudio Sanchez
- Port Fuel Injection, a type of fuel injection used in automobiles
- Pay For Inclusion, Paid inclusion search engines that charge money to include Web sites in their index
- Pre-flight inspection, inspection carried out by the pilot before flying an aircraft