Perse may refer to:
- Perse, Persa or Perseis, an Oceanid, a daughter of Oceanus and Tethys in Greek mythology, wife of Helios
- The Perse School, an independent co-educational school in Cambridge, England
- Perse School for Girls, an independent girls school in Cambridge, England
- Stephen Perse, the founder of The Perse School
- Saint-John Perse, a French diplomat and poet
- Broderie perse, a sewing technique
- Perse, a genus of fossil snails in the family Fasciolariidae
- Virachola perse, a type of butterfly
- A river and a waterfall in Koknese manor park, Aizkraukle District, Latvia