OIS may mean:
- Overnight indexed swap, a type of interest rate swap
- Object Oriented Input System, a cross-platform input system
- Optical IP Switching, a computer optical network architecture
- Optical Image Stabilization, a technique to stabilize the image in digital cameras and camcorders in order to increase picture quality
- Ocular ischemic syndrome, a medical condition which blocks arterial blood flow to the eye
- Oxygen isotope stages of the Weichselian glaciation used in paleoclimatology
- Objective Interface Systems, a communications software and hardware company
- Oeiras International School, an international school in Oeiras (suburb of Lisbon), Portugal
- Oxford International School, an international English-medium school in Dhaka, Bangladesh
- Oulu International School, a small public not-for-profit international school in Oulu, Finland
- Ops in Surgery, The St George's Surgical Society, a society at St George's University
- Örgryte IS, a Swedish sports club based in Gothenburg
- Office Information System, an operating system used by WANG computers.
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