Occlusion may refer to:
- Occlusion (dentistry), the manner in which the upper and lower teeth come together when the mouth is closed
- Occlusion effect, an audio phenomenon that occurs when one closes the opening into the ear canal and the loudness of low pitched sounds increases
- Occlusion miliaria, a skin condition that is accompanied by anhidrosis and increased susceptibility to heat
- Occlusion culling or hidden surface determination, a 3D computer graphics process
- Ambient occlusion, a shading method used in 3D computer graphics
- Screen Space Ambient Occlusion (SSAO), a computer graphics rendering technique
- Vascular occlusion, blockage of a blood vessel