NPSL may stand for:
- National Premier Soccer League - a soccer league considered to be at the 4th level of the American Soccer Pyramid
- National Professional Soccer League (1967) - a 1960s U.S. outdoor soccer league.
- National Professional Soccer League (1984–2001) - a 1990s U.S. indoor soccer league.
- National Premier Soccer League (South Africa) - a 1971-95 South African soccer league.