Transport Mechanisms
The transport of norepinephrine back into presynaptic cell is made possible by the cotransport with Na+ and Cl-. The sequential binding of the ions results in the eventual reuptake of norepinephrine. The ion gradients of Na+ and Cl- make this reuptake energetically favorable. The gradient is generated by the Na+/K+-ATPase which transports three sodium ions out and two potassium ions into the cell. NETs have conductances similar to those of ligand-gated ion channels. The expression of NET results in a leak-channel activity.
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