The nerve Growth factor IB (NGFIB) also known as Nur77 or NR4A1 (nuclear receptor subfamily 4 group A member 1) is a protein that in humans is encoded by the NR4A1 gene.
Nerve Growth factor IB is a member of the Nur nuclear receptor family of intracellular transcription factors. NGFIB is involved in cell cycle mediation, inflammation and apoptosis.
The NGFIB protein plays a key role in mediating inflammatory responses in macrophages. In addition, subcellular localization of the NGFIB protein appears to play a key role in the survival and death of cells.
Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Read more about Nerve Growth Factor IB: Structure, Function, Biochemistry, Evolution and Homology, Pathology, Interactions
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