The nerve Growth factor IB (NGFIB) also known as Nur77 or NR4A1 (nuclear receptor subfamily 4 group A member 1) is a protein that in humans is encoded by the NR4A1 gene.
Nerve Growth factor IB is a member of the Nur nuclear receptor family of intracellular transcription factors. NGFIB is involved in cell cycle mediation, inflammation and apoptosis.
The NGFIB protein plays a key role in mediating inflammatory responses in macrophages. In addition, subcellular localization of the NGFIB protein appears to play a key role in the survival and death of cells.
Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Read more about Nerve Growth Factor IB: Structure, Function, Biochemistry, Evolution and Homology, Pathology, Interactions
Famous quotes containing the words nerve, growth and/or factor:
“Tom: All right, boys. C’mon. Why don’t you say I’m a yellow belly and a big mouth at that?
Shep: You yellow? Who thinks you’re yellow? Did you hear what he said? A guy who’s got the nerve to marry? That’s more than Flash Gordon ever did.”
—Billy Wilder (b. 1906)
“Hence, the less government we have, the better,—the fewer laws, and the less confided power. The antidote to this abuse of formal Government, is, the influence of private character, the growth of the Individual; the appearance of the principal to supersede the proxy; the appearance of the wise man, of whom the existing government, is, it must be owned, but a shabby imitation.”
—Ralph Waldo Emerson (1803–1882)
“It is change, continuing change, inevitable change, that is the dominant factor in society today. No sensible decision can be made any longer without taking into account not only the world as it is, but the world as it will be.... This, in turn, means that our statesmen, our businessmen, our everyman must take on a science fictional way of thinking.”
—Isaac Asimov (1920–1992)