Biochemistry
Nerve Growth factor IB binds as a monomer or homodimer to response element NBRE and as a homodimer to NurRE. It is also capable of heterodimerising with COUP-TF (an orphan nuclear receptor) and retinoid X receptor (RXR) in mediating transcription in response to retinoids.
The binding sites on the response elements for NGFI-B, which are common to the two other members of the Nur family, are :
- NBRE - 5’-A/TAAAGGTCA,
- NurRE - a AAAT(G/A)(C/T)CA repeat,
- RXR - DX, a motif.
Read more about this topic: Nerve Growth Factor IB