Napo or NAPO may refer to
- Napo County (那坡县), Baise, Guangxi, China
- Napo River, a tributary to the Amazon River that rises in Ecuador
- Napo Province, a province in Ecuador
- Napo District, a district of Maynas, Peru
- Napo, Tianyang County (那坡镇), town in Guangxi, China
- Napo (trade union), a UK trade union that represents probation officers and CAFCASS reporters
- National Association of Professional Organizers
- Novosibirsk Aircraft Production Association, an aircraft production company in Russia
- National Association of Police Organizations, US umbrella lobbying organization of police officers and officers associations