MWC may refer to:
- Married... with Children, a U.S. television situation comedy
- Married White Couple, personal advertisement acronym
- Mennonite World Conference
- The Minnesota Wrecking Crew, a Canadian sketch comedy troupe
- Mobile World Congress, annual conference and trade show for the mobile phone industry in Barcelona
- MWC model, biochemical model of protein transitions
- Mount Wilson Catalogue, an astronomical catalogue of emission-line stars
- Mountain West Conference, a U.S. collegiate athletic conference
- Multiply-with-carry, mathematical algorithm for a simple pseudo-random number generator
- Music World Creations, a Canadian-based independent record label, the label of 1970s Canadian rock trio The Stampeders
- Music World Corporation, a U.S. music publishing company founded by Academy Award winning songwriter Robert B. Sherman
- Match Winning Chances in backgammon