The acronym MSH may stand for one of several things, including:
- Markham Stouffville Hospital - A hospital in Markham, Ontario
- Marvel Super Heroes - an acronym commonly used by comic, arcade game and role-playing fans.
- Maxwell's Silver Hammer - a song by The Beatles
- Melanocyte-stimulating hormone - a hormone produced in the pituitary gland, and related to skin pigmentation.
- Mississippi State Hospital - a mental hospital in Rankin County, Mississippi
- Monad Shell — a former name for the Microsoft Windows PowerShell
- Mossley Hill railway station, England; National Rail station code MSH.
- Mount St. Helens, in the United States is often abbreviated as MSH.
- Mount Sinai Hospital (Toronto) - a University of Toronto affiliated hospital.
- Fulton County Charter High School of Mathematics and Science - a former charter school in Georgia (U.S. state) also known as Math/Science High.
- Mycothiol, an unusual thiol that is found in Actinobacteria.