Mouse KO
In ovarian conditional mouse knockout of SMAD4, the granulosa cells undergo premature luteinization and express lower levels of follicle-stimulating hormone receptors (FSHR) and higher levels of luteinizing hormone receptors (LHR). This may be due in part to impairment of bone morphogenetic protein-7 effects as BMP-7 uses the SMAD4 signaling pathway.
Read more about this topic: Mothers Against Decapentaplegic Homolog 4
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“A mouse does not run into the mouth of a sleeping cat.”
—Estonian. Trans. by Ilse Lehiste (1993)