Mouse KO
In ovarian conditional mouse knockout of SMAD4, the granulosa cells undergo premature luteinization and express lower levels of follicle-stimulating hormone receptors (FSHR) and higher levels of luteinizing hormone receptors (LHR). This may be due in part to impairment of bone morphogenetic protein-7 effects as BMP-7 uses the SMAD4 signaling pathway.
Read more about this topic: Mothers Against Decapentaplegic Homolog 4
Famous quotes containing the word mouse:
“It is as when a migrating army of mice girdles a forest of pines. The chopper fells trees from the same motive that the mouse gnaws them,—to get his living. You tell me that he has a more interesting family than the mouse. That is as it happens.”
—Henry David Thoreau (1817–1862)