Mouse KO
In ovarian conditional mouse knockout of SMAD4, the granulosa cells undergo premature luteinization and express lower levels of follicle-stimulating hormone receptors (FSHR) and higher levels of luteinizing hormone receptors (LHR). This may be due in part to impairment of bone morphogenetic protein-7 effects as BMP-7 uses the SMAD4 signaling pathway.
Read more about this topic: Mothers Against Decapentaplegic Homolog 4
Famous quotes containing the word mouse:
“When out an old mouse bolted in the wheats
With all her young ones hanging at her teats;”
—John Clare (1793–1864)