Mouse KO
In ovarian conditional mouse knockout of SMAD4, the granulosa cells undergo premature luteinization and express lower levels of follicle-stimulating hormone receptors (FSHR) and higher levels of luteinizing hormone receptors (LHR). This may be due in part to impairment of bone morphogenetic protein-7 effects as BMP-7 uses the SMAD4 signaling pathway.
Read more about this topic: Mothers Against Decapentaplegic Homolog 4
Famous quotes containing the word mouse:
“Why do precisely these objects which we behold make a world? Why has man just these species of animals for his neighbors; as if nothing but a mouse could have filled this crevice?”
—Henry David Thoreau (1817–1862)