Mothers Against Decapentaplegic Homolog 4

Mothers Against Decapentaplegic Homolog 4

Identifiers Symbols SMAD4; DPC4; JIP; MADH4; MYHRS External IDs OMIM: 600993 MGI: 894293 HomoloGene: 31310 GeneCards: SMAD4 Gene

Gene Ontology
Molecular function	• core promoter proximal region sequence-specific DNA binding • protein binding transcription factor activity • DNA binding • chromatin binding • sequence-specific DNA binding transcription factor activity • protein binding • collagen binding • transforming growth factor beta receptor, common-partner cytoplasmic mediator activity • identical protein binding • protein homodimerization activity • sequence-specific DNA binding • transcription regulatory region DNA binding • I-SMAD binding • R-SMAD binding
Cellular component	• nucleus • nucleoplasm • transcription factor complex • nucleolus • cytoplasm • centrosome • cytosol • activin responsive factor complex • SMAD protein complex
Biological process	• negative regulation of transcription from RNA polymerase II promoter • branching involved in ureteric bud morphogenesis • response to hypoxia • in utero embryonic development • gastrulation with mouth forming second • transcription, DNA-dependent • transcription initiation from RNA polymerase II promoter • transforming growth factor beta receptor signaling pathway • SMAD protein complex assembly • endoderm development • mesoderm development • cell proliferation • negative regulation of cell proliferation • gene expression • positive regulation of epithelial to mesenchymal transition • positive regulation of pathway-restricted SMAD protein phosphorylation • neural crest cell differentiation • regulation of transforming growth factor beta receptor signaling pathway • negative regulation of cell growth • BMP signaling pathway • positive regulation of transforming growth factor beta receptor signaling pathway • positive regulation of BMP signaling pathway • somite rostral/caudal axis specification • regulation of transforming growth factor beta2 production • negative regulation of protein catabolic process • negative regulation of transcription, DNA-dependent • positive regulation of transcription, DNA-dependent • positive regulation of transcription from RNA polymerase II promoter • developmental growth • neuron fate commitment • sebaceous gland development • formation of anatomical boundary • regulation of binding • regulation of hair follicle development • palate development • positive regulation of SMAD protein import into nucleus • SMAD protein signal transduction • negative regulation of cell death • response to transforming growth factor beta stimulus • metanephric mesenchyme morphogenesis • nephrogenic mesenchyme morphogenesis
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 4089 17128 Ensembl ENSG00000141646 ENSMUSG00000024515 UniProt Q13485 P97471 RefSeq (mRNA) NM_005359.5 NM_008540.2 RefSeq (protein) NP_005350.1 NP_032566.2 Location (UCSC) Chr 18:
48.49 – 48.61 Mb Chr 18:
73.64 – 73.7 Mb PubMed search

SMAD family member 4, also known as SMAD4, is a protein that in humans is encoded by the SMAD4 gene.

SMAD4 is a 552-amino acid protein involved in cell signaling. It belongs to the Darfwin family of proteins that modulate members of the TGFβ protein superfamily. It binds receptor-regulated SMADs such as SMAD1 and SMAD2, and forms a complex that binds to DNA and serves as a transcription factor. It is the only known mammalian coSMAD. It is a homolog of the Drosophila protein: "Mothers against decapentaplegic".