Mono often refers to:
- Mono-, numerical prefix representing anything single, e.g. as in monorail, a train system using a single rail, as opposed to the conventional two-rail system
- Monaural or monophonic sound, which uses a single channel, as opposed to stereophonic (or stereo) sound
- Infectious mononucleosis, also referred to as "glandular fever", "kissing disease" or "mono"
Mono may also refer to: