Mercurio may refer to:
- El Mercurio, a conservative Chilean newspaper
- Mercurio the 4-D Man, a fictional character that appears in the Marvel Universe
- Mercurio (wrestler), the ring name of a Mexican professional wrestler
People with the surname Mercurio:
- Angelo Mercurio (1936–2006), Italian-American mobster
- Gus Mercurio (1928–2010), American-born Australian character actor
- Jed Mercurio (21st century), British writer
- Keith Mercurio (born 1982), American politician
- Paul Mercurio (born 1963), Australian actor and dancer