Mathewson may refer to one of the following:
People:
- Christy Mathewson (1880 - 1925), baseball player
- Courtney Mathewson, water polo player
- Elisha Mathewson (1767 - 1853), US senator
- George Mathewson, Chairman of the Royal Bank of Scotland
- Henry Mathewson, baseball pitcher
- Katherine Mathewson, Canadian political candidate
- Ron Mathewson, a jazz musucian
Places:
- Christy Mathewson-Memorial Stadium
- Mathewson Farm
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