Marsalis is the surname of an American family of jazz musicians including (from eldest to youngest):
- Ellis Marsalis, pianist; father of the others listed here
- Branford Marsalis, saxophonist
- Marsalis Music, a record label founded by Branford Marsalis
- Wynton Marsalis, trumpet player
- Delfeayo Marsalis, trombone player and producer
- Jason Marsalis, drummer and percussionist
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