Late Life
Isabella died in childbirth in 1498, putting a damper on Portuguese ambitions to rule in Spain, which various rulers had harbored since the reign of King Ferdinand I (1367–1383). Manuel and Isabella's young son Miguel was for a period the heir apparent of Castile and Aragon, but his death in 1500 ended these ambitions.
Manuel's next wife, Maria of Aragon, was his first wife's sister, but not the oldest surviving one. That was rather Joanna of Castile, who had issue.
In 1506 the Pope Julius II gave Manuel I a Golden Rose. Later in 1514 Pope Leo X also gave Manuel I a second Golden Rose. Manuel I became the first individual to receive more than one Golden Rose.
The Jerónimos Monastery in Lisbon houses Manuel's tomb. His son João succeeded him as king.
Read more about this topic: Manuel I Of Portugal
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