Mahone is a surname, and may refer to;
- William Mahone, American politician.
- Otelia Butler Mahone, a nurse and the wife of Confederate Major General William Mahone.
- Robert B. Mahone, former Consul of the United States at Nuevo Laredo, Mexico
- William T. Mahone Jr.
- Austin Mahone, a signed recording artist who came to prominence from uploading videos on YouTube
Fictional characters with the Mahone surname include;
- Alexander Mahone, a character from the television show Prison Break.