Maffei is an Italian surname. It may refer to:
- Alessandro R. Maffei, Italian designer
- Alessandro, Marquis de Maffei, Bavarian general
- Andrea Maffei, Italian poet and librettist
- Antonio Maffei, Italian art historian
- Antonio Maffei, member of the Pazzi Conspiracy
- Arturo Maffei, Italian athlete
- Bernardino Maffei, Italian archbishop and cardinal
- Clara Maffei, Italian lady of letters
- Dan Maffei, United States Congressman representing the 25th Congressional District of New York
- Fabrizio Maffei, Italian journalist and television presenter
- Francesco Maffei, Italian painter
- Francesco Maffei or Scipione Maffei, Italian archaeologist and man of letters
- Giovanni Pietro Maffei (1533–1603), Italian Jesuit and writer.
- Giovanni Andrea Maffei, Italian politician
- Joseph Anton von Maffei, German industrialist
- Leonard Maffei, Italian-American bicycle racer
- Marcantonio Maffei, Italian cardinal
- Michele Maffei, Italian fencer
- Neal Maffei, London Based American Performance Artist
- Nicola Maffei, Italian politician
- Orazio Maffei, Italian cardinal
- Paolo Maffei, Italian astrophysicist
- Paolo Alessandro Maffei (1653 — 1716), Italian antiquarian humanist
- Scipione Maffei, Italian playwright and literary critic
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