Lyme can refer to:

In biology:

  • Lyme disease, an infectious disease carried by ticks caused by bacteria of genus Borrelia

In geography:

  • United States of America
    • Lyme, Connecticut, a town in southeastern Connecticut, the namesake of Lyme disease
    • Lyme, New Hampshire, a town in western New Hampshire
    • Lyme, New York, a town in New York along the Lake Ontario shoreline
  • United Kingdom
    • Lyme Bay, an embayment of the English Channel
    • Lyme Handley, a civil parish near Disley in Cheshire
    • Lyme Park, an estate in County Cheshire
    • Lyme Regis, a town in West Dorset
    • Forest of Lyme, a historic area of forest in Cheshire, Derbyshire and Staffordshire
  • South Africa
    • Lyme Park, Gauteng, a suburb of Johannesburg

LYME can refer to:

In computing:

  • The web solution stack LYME which consists of Linux, Yaws, Mnesia and Erlang