Lyme can refer to:
In biology:
- Lyme disease, an infectious disease carried by ticks caused by bacteria of genus Borrelia
In geography:
- United States of America
- Lyme, Connecticut, a town in southeastern Connecticut, the namesake of Lyme disease
- Lyme, New Hampshire, a town in western New Hampshire
- Lyme, New York, a town in New York along the Lake Ontario shoreline
- United Kingdom
- Lyme Bay, an embayment of the English Channel
- Lyme Handley, a civil parish near Disley in Cheshire
- Lyme Park, an estate in County Cheshire
- Lyme Regis, a town in West Dorset
- Forest of Lyme, a historic area of forest in Cheshire, Derbyshire and Staffordshire
- South Africa
- Lyme Park, Gauteng, a suburb of Johannesburg
LYME can refer to:
In computing:
- The web solution stack LYME which consists of Linux, Yaws, Mnesia and Erlang
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