Littlewood is a surname, and may refer to:
- Barclay Littlewood, British entrepreneur
- Dominic Littlewood, British television presenter and entrepreneur
- Dudley E. Littlewood, British mathematician
- Joan Littlewood, British actress and theatre director
- John Edensor Littlewood, British mathematician
- John Littlewood (chess player), British chess player
- Mark Littlewood, Director General of the Institute of Economic Affairs
- Peter Littlewood, British physicist