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- Ed Salem, football player (Birmingham) born Tucson, Arizona
- Sonia Sanchez, poet (Birmingham)
- Steve Sanders, anchor for Chicago's WGN News Birmingham
- David Satcher, surgeon general (Anniston)
- Zelda Fitzgerald, writer (Montgomery)
- Coretta Scott King, civil rights leader (Marion)
- Richard M. Scrushy, founder and former CEO of HealthSouth (Selma)
- Doc Scurlock,Josiah Gordon Scurlock a founding member of the Lincoln County New Mexico Regulators, member of Billy the Kid's gang. born (Tallapoosa)
- Jay Sebring, Charles Manson murder victim (Birmingham)
- Waldo Semon, inventor of vinyl (Demopolis)
- David Sessions, member of the Alabama Legislature (Grand Bay)
- Jeff Sessions, current United States Senator (Dothan)
- Joe Sewell, baseball player (Titus)
- Luke Sewell, baseball player (Titus)
- Rip Sewell, baseball player (Decatur)
- Glenn Shadix, actor (Bessemer)
- Tommy Shaw, rock musician (Montgomery)
- Earnie Shavers, former heavyweight boxer (Garland)
- Richard C. Shelby, current United States Senator (Birmingham)
- Ashton Shepherd, country singer (Coffeeville)
- Fred Shuttlesworth, civil rights activist (Birmingham)
- George Siebels, mayor of Birmingham (1967-1975), state representative (1975-1990) (Birmingham)
- Don Siegelman, former governor of Alabama (1999–2003) (Mobile)
- Eugene Sledge; World War II veteran, teacher, writer (Mobile)
- Percy Sledge, soul singer (Leighton)
- Rickey Smiley, comedian (Birmingham)
- Albert Lee Smith, Jr., representative from Alabama's 6th congressional district (1981-1983) (Birmingham)
- Ella Gaunt Smith, doll manufacturer (Roanoke)
- Leighton W. Smith, Jr., admiral- United States Navy (Mobile)
- Holland Smith, General - United States Marine Corps World War II, father of amphibious warfare (Hatchechubbie)
- Ozzie Smith, Baseball player (Mobile)
- Johnny Smith, jazz guitarist (Birmingham)
- Thomas M. Smith, district attorney (Tuscaloosa)
- Zeke Smith, American football player (Uniontown)
- John Sparkman, United States Senator (1946–1979) (Hartselle)
- Chauncey Sparks, governor (1943-1947) (Eufaula)
- Mark Spencer, President/CEO of Digium (Huntsville)
- Octavia Spencer, actress (Montgomery)
- The Springs (band), band (Enterprise)
- Ken Stabler, NFL player- The University of Alabama and The Oakland Raiders (Foley)
- John Stallworth, NFL player- Pittsburgh Steelers (Tuscaloosa)
- Bart Starr, NFL player- The University of Alabama- Green Bay Packers (Montgomery)
- Donald W. Stewart, United States Senator (Anniston)
- Mike Stewart (novelist), author (Vredenburgh)
- Warren St. John, author, journalist (Birmingham)
- Luther Strange, Attorney General of Alabama since 2011 (Mountain Brook)
- T. S. Stribling, author (Florence)
- Gail Strickland, character actress (Birmingham)
- Hut Stricklin, NASCAR driver (Calera)
- Ruben Studdard, 2003 American Idol winner (Birmingham)
- Jimmy Lee Sudduth, artist and blues musician (Fayette)
- Pat Sullivan, American football player (Birmingham)
- Don Sutton, baseball player (Clio)
- Barret Swatek, actress and comedian (Birmingham)
- Ward Swingle, jazz arranger and composer (Mobile)
Read more about this topic: List Of People From Alabama