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- Philip Ober, stage and screen actor (Fort Payne)
- Benjamin Obomanu, NFL player- Seattle Seahawks (Selma)
- Scott Oden, writer (Somerville)
- Cathy O'Donnell, film and television actress (Siluria)
- Spooner Oldham; songwriter, keyboardist (Center Star)
- Stan O'Neal, chairman & CEO of Merrill Lynch (Roanoke)
- Osceola, Seminole leader (Tallassee)
- Victoria Osteen, co-pastor of Lakewood Church (Huntsville)
- Randy Owen, lead singer- Alabama (Fort Payne)
- Jesse Owens, track and field athlete (Oakville)
- Terrell Owens, American football player (Alexander City)
Read more about this topic: List Of People From Alabama