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- Bobby Eaton, pro wrestler (Huntsville)
- Cleveland Eaton, jazz bassist (Birmingham)
- Dennis Edwards, soul music singer (Birmingham)
- Jack Edwards, representative from Alabama's 1st congressional district (1965-1985) (Mobile)
- Joe F. Edwards, Jr., astronaut (Roanoke and Lineville) born Richmond, Virginia
- Carl Elliott, representative from Alabama's 7th congressional district from 1949 to 1965 (Jasper)
- Patricia Ellis, film actress (Birmingham)
- Eric Esch, a.k.a. Butterbean, boxer (Jasper)
- James Reese Europe; bandleader, composer (Mobile)
- Terry Everett, representative from Alabama's 2nd congressional district (1993-2009) (Enterprise)
Read more about this topic: List Of People From Alabama