Application To Medicine
A likelihood ratio of greater than 1 indicates the test result is associated with the disease. A likelihood ratio less than 1 indicates that the result is associated with absence of the disease. Tests where the likelihood ratios lie close to 1 have little practical significance as the post-test probability (odds) is little different from the pre-test probability, and as such is used primarily for diagnostic purposes, and not screening purposes. When the positive likelihood ratio is greater than 5 or the negative likelihood ratio is less than 0.2 (i.e. 1/5) then they can be applied to the pre-test probability of a patient having the disease tested for to estimate a post-test probability of the disease state existing. In summary, the pre-test probability refers to the chance that an individual has a disorder or condition prior to the use of a diagnostic test. It allows the clinician to better interpret the results of the diagnostic test and helps to predict the likelihood of a true positive (T+) result.
Research suggests that physicians rarely make these calculations in practice, however, and when they do, they often make errors. A randomized controlled trial compared how well physicians interpreted diagnostic tests that were presented as either sensitivity and specificity, a likelihood ratio, or an inexact graphic of the likelihood ratio, found no difference between the three modes in interpretation of test results.
Read more about this topic: Likelihood Ratios In Diagnostic Testing
Famous quotes containing the words application to, application and/or medicine:
“The receipt to make a speaker, and an applauded one too, is short and easy.—Take of common sense quantum sufficit, add a little application to the rules and orders of the House, throw obvious thoughts in a new light, and make up the whole with a large quantity of purity, correctness, and elegancy of style.”
—Philip Dormer Stanhope, 4th Earl Chesterfield (1694–1773)
“By an application of the theory of relativity to the taste of readers, to-day in Germany I am called a German man of science, and in England I am represented as a Swiss Jew. If I come to be regarded as a bête noire the descriptions will be reversed, and I shall become a Swiss Jew for the Germans and a German man of science for the English!”
—Albert Einstein (1879–1955)
“Good medicine is bitter, but it cures illness.”
—Chinese proverb.
Confucius.