Ledesma refers to:
People with the surname Ledesma:
- Arts
- Alan Ledesma (1977 - 2008), Mexican actor
- Blas de Ledesma (17th century), Spanish painter
- Carlo Ledesma (born 1975), Filipino film director
- Clara Ledesma (1924-1999), Dominican painter
- Dondi Ledesma (died 2009), Filipino bassist
- Inda Ledesma (1926 - 2010), Argentine actress and theater director
- Jaime Ledesma (born 1973), Puerto Rican radio disc jockey, music producer, director
- Josef de Ledesma (1630 - 1670), Spanish painter
- Jordhy Ledesma (born 1978), Dominican poet
- Kuh Ledesma (born 1955), Filipino jazz vocalist
- Public affairs
- Antonio Ledesma (born 1943), Archbishop of Cagayan de Oro, Philippines
- Antonio Ledesma Jayme (1854 - 1937), Filipino lawmaker
- Jesus Ledesma Aguilar (1963 - 2006), Mexican national executed in Texas
- Ramiro Ledesma Ramos (1905 - 1936), Spanish politician
- Sports
- Aaron Ledesma (born 1971), American professional baseball player
- Ángel Ledesma (born 1993), Ecuadorian football player
- Arturo Ledesma (born 1988), Mexican football player
- Carlos Ledesma (born 1964), Argentine football player
- Christian Ledesma (born 1976), Argentine racing driver
- Cristian Daniel Ledesma (born 1982), Argentine professional football player
- Cristian Raúl Ledesma (born 1978), Argentine professional football player
- Cristian Rolando Ledesma (born 1987), Paraguayan professional football player
- Damián Ledesma (born 1982), Argentine football player
- Emmanuel Ledesma (born 1988), Argentine professional football player
- Ernesto Ledesma (1931 - 2011), Uruguayan football player
- Jorge Ledesma (born 1932), Argentine golfer
- Mario Ledesma (born 1973), Argentine rugby union football player
- Pablo Ledesma (born 1984), Argentine professional football player
- Spider Ledesma (born 1964), American basketball player
- Places
- Clodomiro Ledesma, Entre Ríos, Argentina
- Doñinos de Ledesma, Salamanca, Spain
- La Mata de Ledesma, Salamanca, Spain
- Ledesma, Salamanca, Spain
- Libertador General San Martín, Jujuy, Argentina (founded and still colloquially known as "Ledesma")
- Other
- Club Martín Ledesma, football club in Paraguay
- Ledesma S.A.A.I., Argentine agribusiness firm