Kwame or Kwamé is a Twi and Akan day name given to a boy born on a Saturday, originating in Ghana. People with this name include:
- Osei Kwame Panyin, an 18th century leader of the Ashanti Confederacy, located in what is today southern and central Ghana
- Kwame Anthony Appiah, a Ghanaian-British philosopher of semantics and racism
- Kwame Brown, an American basketball player in the NBA
- Kwamé Holland, an American rapper who enjoyed brief popularity during the golden age of hip hop; reemerged as a music producer named K1 Million
- Kwame Jackson, one of the two final candidates on Donald Trump's American television reality series The Apprentice.
- Kwame Kilpatrick, former mayor of Detroit, Michigan
- Kwame Nkrumah, a Ghanaian politician and for a time Life President (originally Francis Nwia-Kofi Ngonloma) and one of the most influential founders of Pan-Africanism
- Kwame Raoul, a Democratic member of the Illinois Senate, representing the 13th district since 2004
- Kwame Somburu, an American socialist political activist
- Kwame Tucker, a Bermudan cricketer
- Kwame Ture, the name adopted by Stokely Carmichael, a Trinidadian-American black activist and leader of the Student Nonviolent Coordinating Committee and the Black Panther Party to honor Kwame Nkrumah and Ahmed Sékou Touré
In addition:
- Kwame (Captain Planet), a character in the television series Captain Planet and the Planeteers
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