Keyes is a common surname, from Anglo--Saxons tribe of Great Britain. It may refer to several notable people:
- Alan Keyes (born 1950), American politician and diplomat
- Baron Keyes, a title in the Peerage of the United Kingdom
- Captain Jacob Keyes and his daughter Miranda, fictional characters from the video game Halo
- Carlito Keyes, fictional character
- Charles Henry Keyes (1858–1925), American educator
- Charles Reuben Keyes (1871-1951), American archaeologist
- Charles Rollin Keyes (1864-1942), American geologist
- Daniel Keyes (born 1927), American author
- Dan Keyes, American Musician of Recover (band)
- Erasmus D. Keyes (1810-1895), American general
- Eric Keyes (born 1969), guitarist
- Evelyn Keyes (1916-2008), American actress
- Frances Parkinson Keyes (1885-1970), American author
- Geoffrey Charles Tasker Keyes (1917-1941), VC, British Major killed in the raid on Rommel
- Geoffrey Keyes (1888-1967), major general in the U.S. Army during World War II
- Gregory Keyes (born 1963), science fiction and fantasy writer
- Henry Keyes (1810-1870), American politician and railroad executive
- Henry W. Keyes (1863-1938), politician
- Homer Eaton Keyes (1875-1938), Dartmouth professor
- Jocelyn Marcel Keyes (born 1950), American political activist
- Joe Keyes (c.1907-1950), American jazz trumpeter
- Ken Keyes (politician) (born 1930), Ontario politician
- Ken Keyes, Jr. (1921-1995), author and lecturer
- Laurel Elizabeth Keyes (died 1983), counselor
- Marian Keyes (born 1963), Irish writer
- Maya Keyes (born 1985), daughter of American politician and diplomat Alan Keyes
- Michael Keyes, former Irish politician
- Perley Keyes (1774-1834), New York politician
- Ralph Keyes (born 1961), Rugby Player
- Ralph Keyes (author) (born 1945)
- Roger John Brownlow Keyes, 1st Baron Keyes (1872-1945), British admiral and hero
- Roswell Keyes Colcord (1839-1939), Governor of Nevada from 1891 to 1895
- Sammy Keyes, fictional character
- Sidney Keyes (1922-1943), English poet and soldier during World War II.
- Stan Keyes (born 1953), Canadian politician
- Thomas Keyes (1523-1571), Royal gatekeeper to Queen Elizabeth I of England
- Wade Keyes (1821-1879), Confederate politician
Keyes may also refer to several places in the United States:
- Keyes, California
- Keyes, Oklahoma