Kernan may refer to:
- Edward Kernan (1771–1844), Irish clergyman
- Francis Kernan (1816–1892), American politician
- James Lawrence Kernan (1838–1912), American theater manager and philanthorpist from Baltimore, Maryland
- Joe Kernan (politician) (born 1946), American politician
- Joe Kernan (Gaelic footballer) (born 1954), Irish footballer
- Joseph D. Kernan, American admiral
- Kernan "Skip" Hand, Louisiana politician
- William F. Kernan, American general
- Kernan, County Down, a townland in County Down, Northern Ireland
- Kernan, County Armagh, a townland in County Armagh, Northern Ireland
Kernan may also refer to:
- James Lawrence Kernan Hospital, hospital located in Woodlawn, Maryland, United States