Discovery of The Effect of Lithium On Mania
After the war, Cade recuperated very briefly in Heidelberg Hospital, then took up a position at Bundoora Repatriation Mental Hospital in Melbourne. It was at an unused kitchen in Bundoora where he conducted crude experiments which led to the discovery of lithium as a treatment of bipolar disorder. These experiments mostly consisted of injecting urine from mentally ill patients into the abdomen of guinea pigs. These would appear to die faster than when healthy persons' urine was used, leading him to think that perhaps more uric acid was present in the samples provided by his mentally ill patients. Then, in an effort to increase the water solubility of uric acid, lithium urate was added to the solution. Cade found that in the guinea pigs injected with the lithium urate solution, toxicity was greatly reduced. However, his use of careful controls in his experiments revealed that the lithium ion had a calming effect by itself. After ingesting lithium himself to ensure its safety in humans, Cade began a small-scale trial of lithium citrate and/or lithium carbonate on some of his patients diagnosed with mania, dementia præcox or melancholia, with outstanding results. The calming effect was so robust that Cade speculated that mania was caused by a deficiency in lithium.
While Cade's results appeared highly promising, side-effects of lithium in some cases lead to non-compliance. Toxicity of lithium led to several deaths of patients undergoing lithium treatment. The problem of toxicity was greatly reduced when suitable tests were developed to measure the lithium level in the blood. Moreover, as a naturally-occurring chemical, lithium salt could not be patented, meaning that its manufacturing and sales were not considered commercially viable. These factors prevented its widespread adoption in psychiatry for some years, particularly in the United States, where its use was banned until 1970.
Read more about this topic: John Cade
Famous quotes containing the words discovery of the, discovery of, discovery, effect and/or mania:
“Your discovery of the contradiction caused me the greatest surprise and, I would almost say, consternation, since it has shaken the basis on which I intended to build my arithmetic.... It is all the more serious since, with the loss of my rule V, not only the foundations of my arithmetic, but also the sole possible foundations of arithmetic seem to vanish.”
—Gottlob Frege (1848–1925)
“As the mother of a son, I do not accept that alienation from me is necessary for his discovery of himself. As a woman, I will not cooperate in demeaning womanly things so that he can be proud to be a man. I like to think the women in my son’s future are counting on me.”
—Letty Cottin Pogrebin (20th century)
“Next to the striking of fire and the discovery of the wheel, the greatest triumph of what we call civilization was the domestication of the human male.”
—Max Lerner (b. 1902)
“I have no faith in human perfectability. I think that human exertion will have no appreciable effect upon humanity. Man is now only more active—not more happy—nor more wise, than he was 6000 years ago.”
—Edgar Allan Poe (1809–1845)
“It is a mania shared by philosophers of all ages to deny what exists and to explain what does not exist.”
—Jean-Jacques Rousseau (1712–1778)