ITK (gene)

ITK (gene)

Identifiers Symbols ITK; EMT; LYK; PSCTK2 External IDs OMIM: 186973 MGI: 96621 HomoloGene: 4051 ChEMBL: 2959 GeneCards: ITK Gene EC number 2.7.10.2

Gene Ontology
Molecular function	• non-membrane spanning protein tyrosine kinase activity • protein binding • ATP binding • phospholipid binding • metal ion binding
Cellular component	• cytosol
Biological process	• cytokine production • NK T cell differentiation • adaptive immune response • cellular defense response • signal transduction • activation of phospholipase C activity • interferon-gamma production • interleukin-4 production • intracellular signal transduction • T cell activation • T cell receptor signaling pathway
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Protein domains Orthologs Species Human Mouse Entrez 3702 16428 Ensembl ENSG00000113263 ENSMUSG00000020395 UniProt Q08881 Q03526 RefSeq (mRNA) NM_005546.3 NM_010583.2 RefSeq (protein) NP_005537.3 NP_034713.2 Location (UCSC) Chr 5:
156.57 – 156.68 Mb Chr 11:
46.33 – 46.39 Mb PubMed search

IL2-inducible T-cell kinase, also known as ITK, is a protein that in humans is encoded by the ITK gene. ITK is a member of the TEC family of kinases and is highly expressed in T cells.