Interleukin 18

Interleukin 18

Identifiers Symbols IL18; IGIF; IL-18; IL-1g; IL1F4 External IDs OMIM: 600953 MGI: 107936 HomoloGene: 1200 ChEMBL: 1741305 GeneCards: IL18 Gene

Gene Ontology
Molecular function	• cytokine activity
Cellular component	• extracellular region • extracellular space • cytosol • apical plasma membrane
Biological process	• MAPK cascade • angiogenesis • osteoblast differentiation • response to hypoxia • inflammatory response • immune response • cell-cell signaling • response to radiation • response to cold • positive regulation of gene expression • regulation of cell adhesion • lung development • sleep • lipopolysaccharide-mediated signaling pathway • positive regulation of chemokine production • positive regulation of granulocyte macrophage colony-stimulating factor production • positive regulation of interferon-gamma production • positive regulation of interleukin-1 beta production • positive regulation of interleukin-17 production • positive regulation of interleukin-8 production • positive regulation of tumor necrosis factor production • positive regulation of natural killer cell proliferation • positive regulation of superoxide anion generation • positive regulation of collagen biosynthetic process • positive regulation of tissue remodeling • chemokine biosynthetic process • T-helper 1 type immune response • type 2 immune response • interleukin-2 biosynthetic process • interferon-gamma biosynthetic process • positive regulation of activated T cell proliferation • interleukin-13 biosynthetic process • granulocyte macrophage colony-stimulating factor biosynthetic process • positive regulation of vascular permeability • positive regulation of neuron apoptotic process • digestive tract morphogenesis • positive regulation of inflammatory response • detection of mechanical stimulus involved in sensory perception of pain • positive regulation of NK T cell proliferation • response to hyperoxia • regulation of blood vessel remodeling • cellular response to hydrogen peroxide • cellular response to mechanical stimulus • cellular response to cAMP • cellular response to interferon-gamma • cellular response to tumor necrosis factor • cellular response to parathyroid hormone stimulus • cellular response to peptide hormone stimulus • cellular response to organic cyclic compound • positive regulation of male germ cell proliferation
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 3606 16173 Ensembl ENSG00000150782 ENSMUSG00000039217 UniProt Q14116 P70380 RefSeq (mRNA) NM_001243211.1 NM_008360.1 RefSeq (protein) NP_001230140.1 NP_032386.1 Location (UCSC) Chr 11:
112.01 – 112.03 Mb Chr 9:
50.58 – 50.58 Mb PubMed search

Interleukin-18 (IL18, also known as interferon-gamma inducing factor) is a protein which in humans is encoded by the IL18 gene. The protein encoded by this gene is a proinflammatory cytokine.