Insulin-like Growth Factor 2 Receptor

Insulin-like Growth Factor 2 Receptor

Identifiers Symbols IGF2R; CD222; CIMPR; M6P-R; MPR1; MPRI External IDs OMIM: 147280 MGI: 96435 HomoloGene: 676 ChEMBL: 3240 GeneCards: IGF2R Gene

Gene Ontology
Molecular function glycoprotein binding
receptor activity
insulin-like growth factor-activated receptor activity
transporter activity
protein binding
insulin-like growth factor binding
mannose binding
phosphoprotein binding
Cellular component nuclear envelope lumen
lysosomal membrane
endosome
integral to plasma membrane
cell surface
endocytic vesicle
trans-Golgi network transport vesicle
Biological process receptor-mediated endocytosis
signal transduction
insulin-like growth factor receptor signaling pathway
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 3482 16004 Ensembl ENSG00000197081 ENSMUSG00000023830 UniProt P11717 Q07113 RefSeq (mRNA) NM_000876.2 NM_010515.2 RefSeq (protein) NP_000867.2 NP_034645.2 Location (UCSC) Chr 6:
160.39 – 160.53 Mb Chr 17:
12.68 – 12.77 Mb PubMed search This article is about the cation-independent mannose 6-phosphate receptor. For the cation-dependent receptor, see cation-dependent mannose-6-phosphate receptor.

In the fields of biochemistry and cell biology, the insulin-like growth factor 2 receptor (IGF2R), also called the cation-independent mannose-6-phosphate receptor (CI-MPR) is a protein that in humans is encoded by the IGF2R gene. IGF2R is a multifunctional protein receptor that binds insulin-like growth factor 2 (IGF2) at the cell surface and mannose-6-phosphate (M6P)-tagged proteins in the trans-Golgi network.

Read more about Insulin-like Growth Factor 2 Receptor:  Structure, Function, Interactions

Famous quotes containing the words growth, factor and/or receptor:

    The windy springs and the blazing summers, one after another, had enriched and mellowed that flat tableland; all the human effort that had gone into it was coming back in long, sweeping lines of fertility. The changes seemed beautiful and harmonious to me; it was like watching the growth of a great man or of a great idea. I recognized every tree and sandbank and rugged draw. I found that I remembered the conformation of the land as one remembers the modelling of human faces.
    Willa Cather (1873–1947)

    In his very rejection of art Walt Whitman is an artist. He tried to produce a certain effect by certain means and he succeeded.... He stands apart, and the chief value of his work is in its prophecy, not in its performance. He has begun a prelude to larger themes. He is the herald to a new era. As a man he is the precursor of a fresh type. He is a factor in the heroic and spiritual evolution of the human being. If Poetry has passed him by, Philosophy will take note of him.
    Oscar Wilde (1854–1900)

    The disinterest [of my two great-aunts] in anything that had to do with high society was such that their sense of hearing ... put to rest its receptor organs and allowed them to suffer the true beginnings of atrophy.
    Marcel Proust (1871–1922)