Insulin-like Growth Factor 2 Receptor

Insulin-like Growth Factor 2 Receptor

Identifiers Symbols IGF2R; CD222; CIMPR; M6P-R; MPR1; MPRI External IDs OMIM: 147280 MGI: 96435 HomoloGene: 676 ChEMBL: 3240 GeneCards: IGF2R Gene

Gene Ontology
Molecular function • glycoprotein binding
• receptor activity
• insulin-like growth factor-activated receptor activity
• transporter activity
• protein binding
• insulin-like growth factor binding
• mannose binding
• phosphoprotein binding
Cellular component • nuclear envelope lumen
• lysosomal membrane
• endosome
• integral to plasma membrane
• cell surface
• endocytic vesicle
• trans-Golgi network transport vesicle
Biological process • receptor-mediated endocytosis
• signal transduction
• insulin-like growth factor receptor signaling pathway
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 3482 16004 Ensembl ENSG00000197081 ENSMUSG00000023830 UniProt P11717 Q07113 RefSeq (mRNA) NM_000876.2 NM_010515.2 RefSeq (protein) NP_000867.2 NP_034645.2 Location (UCSC) Chr 6:
160.39 – 160.53 Mb Chr 17:
12.68 – 12.77 Mb PubMed search This article is about the cation-independent mannose 6-phosphate receptor. For the cation-dependent receptor, see cation-dependent mannose-6-phosphate receptor.

In the fields of biochemistry and cell biology, the insulin-like growth factor 2 receptor (IGF2R), also called the cation-independent mannose-6-phosphate receptor (CI-MPR) is a protein that in humans is encoded by the IGF2R gene. IGF2R is a multifunctional protein receptor that binds insulin-like growth factor 2 (IGF2) at the cell surface and mannose-6-phosphate (M6P)-tagged proteins in the trans-Golgi network.

Read more about Insulin-like Growth Factor 2 Receptor:  Structure, Function, Interactions

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