Problems and Limitations
All implicit solvation models rest on the simple idea that nonpolar atoms of a solute tend to cluster together or occupy nonpolar media, whereas polar and charged groups of the solute tend to remain in water. However, it is important to properly balance the opposite energy contributions from different types of atoms. Several important points have been discussed and investigated over the years.
Read more about this topic: Implicit Solvation
Famous quotes containing the words problems and/or limitations:
“Wittgenstein imagined that the philosopher was like a therapist whose task was to put problems finally to rest, and to cure us of being bewitched by them. So we are told to stop, to shut off lines of inquiry, not to find things puzzling nor to seek explanations. This is intellectual suicide.”
—Simon Blackburn (b. 1944)
“... art transcends its limitations only by staying within them.”
—Flannery O’Connor (1925–1964)