Il1b

IL1B

Identifiers Symbols IL1B; IL-1; IL1-BETA; IL1F2 External IDs OMIM: 147720 MGI: 96543 HomoloGene: 481 GeneCards: IL1B Gene

Gene Ontology
Molecular function	• cytokine activity • interleukin-1 receptor binding • growth factor activity • protein domain specific binding
Cellular component	• extracellular region • extracellular space • cytosol • secretory granule
Biological process	• MAPK cascade • activation of MAPK activity • fever generation • response to hypoxia • positive regulation of protein phosphorylation • chronic inflammatory response to antigenic stimulus • positive regulation of T cell mediated immunity • apoptotic process • inflammatory response • signal transduction • elevation of cytosolic calcium ion concentration • cell-cell signaling • embryo implantation • aging • memory • negative regulation of cell proliferation • response to heat • response to ozone • response to gamma radiation • positive regulation vascular endothelial growth factor production • negative regulation of glucose transport • negative regulation of glutamate secretion • smooth muscle adaptation • cytokine-mediated signaling pathway • hyaluronan biosynthetic process • neutrophil chemotaxis • ovulation • sequestering of triglyceride • positive regulation of vascular endothelial growth factor receptor signaling pathway • positive regulation of fever generation • lipopolysaccharide-mediated signaling pathway • positive regulation of prostaglandin secretion • response to estradiol stimulus • interleukin-1 beta production • positive regulation of granulocyte macrophage colony-stimulating factor production • positive regulation of interferon-gamma production • positive regulation of interleukin-6 production • positive regulation of interleukin-8 production • positive regulation of histone phosphorylation • response to ATP • response to vitamin D • response to L-ascorbic acid • positive regulation of heterotypic cell-cell adhesion • positive regulation of histone acetylation • social behavior • positive regulation of myosin light chain kinase activity • cellular response to drug • wound healing • positive regulation of T cell proliferation • positive regulation of NF-kappaB import into nucleus • positive regulation of apoptotic process • negative regulation of apoptotic process • regulation of I-kappaB kinase/NF-kappaB cascade • positive regulation of I-kappaB kinase/NF-kappaB cascade • response to morphine • negative regulation of MAP kinase activity • protein kinase B signaling cascade • positive regulation of JUN kinase activity • positive regulation of chemokine biosynthetic process • positive regulation of interleukin-2 biosynthetic process • positive regulation of interleukin-6 biosynthetic process • positive regulation of nitric oxide biosynthetic process • positive regulation of angiogenesis • negative regulation of lipid metabolic process • positive regulation of mitosis • positive regulation of transcription, DNA-dependent • positive regulation of transcription from RNA polymerase II promoter • positive regulation of JNK cascade • negative regulation of insulin receptor signaling pathway • positive regulation of protein export from nucleus • regulation of insulin secretion • negative regulation of lipid catabolic process • positive regulation of lipid catabolic process • positive regulation of membrane protein ectodomain proteolysis • positive regulation of sequence-specific DNA binding transcription factor activity • positive regulation of NF-kappaB transcription factor activity • response to glucocorticoid stimulus • positive regulation of cell division • positive regulation of cell adhesion molecule production • positive regulation of calcidiol 1-monooxygenase activity • negative regulation of adiponectin secretion • positive regulation of ERK1 and ERK2 cascade • monocyte aggregation • cellular response to mechanical stimulus • cellular response to organic substance • cellular response to organic cyclic compound • positive regulation of monocyte chemotactic protein-1 production
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 3553 16176 Ensembl ENSG00000125538 ENSMUSG00000027398 UniProt P01584 P10749 RefSeq (mRNA) NM_000576.2 NM_008361.3 RefSeq (protein) NP_000567.1 NP_032387.1 Location (UCSC) Chr 2:
113.59 – 113.59 Mb Chr 2:
129.36 – 129.37 Mb PubMed search

Interleukin-1 beta (IL-1β) also known as catabolin, is a cytokine protein that in humans is encoded by the IL1B gene. IL-1β precursor is cleaved by caspase 1 (interleukin 1 beta convertase). Cytosolic thiol protease cleaves the product to form mature IL-1β.