Huffman is a German American surname likely derived from the German surnames Hoffmann and Hofmann, which in English are also spelled Hoffman and Hofman.
- People
- Booker Huffman (born 1965), American professional wrestler better known as Booker T
- Cady Huffman
- Dave Huffman, former NFL player
- David Huffman, American actor
- David A. Huffman (creator of Huffman coding)
- Felicity Huffman (born 1962), American actress
- George P. Huffman
- James W. Huffman, United States Senator from Ohio (1945–1946)
- Jim Huffman, law professor and candidate for United States Senate from Oregon
- John W. Huffman, professor emeritus of organic chemistry at Clemson University who first synthesised many novel cannabinoids
- Lash Huffman (born 1960), American professional wrestler; brother of Booker T
- Maven Huffman (born 1976), American professional wrestler
- Nate Huffman, former NBA player
- Robert Huffman
- Places
- Huffman Dam, near Fairborn, Ohio
- Huffman, Texas
- Other use
- Huffman Bros. Motor Co, 1920s Indiana based Car Company
- Huffman coding, a data compression algorithm (Huffman tree) by David A. Huffman
- Huffy (also known as Huffman), refers to the company or the bicycle it manufactures